Evidence for a dual mechanism of gastric motor responses to intravenously administered endothelin-1 in anesthetized rats
| Autor: | Pamela J. Hornby, Z. K. Krowicki |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Gastric motility Blood Pressure Vagotomy Inhibitory postsynaptic potential Injections Rats Sprague-Dawley Heart Rate Physiology (medical) Internal medicine Cisterna Magna Heart rate Animals Medicine Anesthesia Endothelin-1 business.industry General Neuroscience Endothelin 1 Rats Blood pressure Endocrinology Injections Intravenous Excitatory postsynaptic potential Gastrointestinal Motility business Endothelin receptor |
| Zdroj: | Journal of Physiology-Paris. 91:203-207 |
| ISSN: | 0928-4257 |
| Popis: | We have recently reproted that endothelin-1 (ET-1), administered intracisternally or microinjected into the DVC of rats, increases gastric motor function via vagal pathways. To determine whether circulating ET-1 acts peripherally or centrally to alter gastric motility, ET-1 (30 and 300 pmol/kg) was administered intravenously in α-chloralose anesthetized rats, while monitoring intragastric pressure, gastric motility, heart rate and blood pressure. Endothelin-1, at a dose of 300 pmol/kg, increased intragastric pressure, stimulated pyloric circular muscle contractile activity, and increased arterial pressure. When ET-1 (300 pmol/kg) was administered after bilateral vagotomy at midcervical level, a marked gastric motor inhibition with an increase in arterial blood pressure were observed. We conclude that the gastric motor effects of circulating ET-1 are a result of central excitatory and peripheral inhibitory actions of the peptide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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