Sexual transmission of hepatitis C virus: cohort study (1981-9) among European homosexual men
| Autor: | P Ebbesen, R J Biggar, N Becker, Mads Melbye, P Wantzin, K Krogsgaard |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Sexual transmission Hepatitis Viral Human Denmark Hepatitis C virus medicine.disease_cause Cohort Studies Internal medicine HIV Seropositivity medicine Humans Cumulative incidence Hepatitis Antibodies Hepatitis B Antibodies Seroconversion General Environmental Science Hepatitis B virus Hepatitis business.industry Incidence (epidemiology) General Engineering virus diseases Homosexuality Sexually Transmitted Diseases Viral General Medicine Hepatitis C Middle Aged medicine.disease Sexual Partners Immunology General Earth and Planetary Sciences business Research Article |
| Zdroj: | BMJ. 301:210-212 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.301.6745.210 |
| Popis: | OBJECTIVE--To determine the prevalence, incidence, and persistence of positivity for antibodies to hepatitis C virus (anti-HCV) and the potential for sexual transmission of the virus. DESIGN--A cohort analysis covering 1981-9 comparing estimated cumulative incidences of and seroconversion rates for anti-HCV with those of hepatitis B core antibody (anti-HBc) and antibodies to the human immunodeficiency virus (anti-HIV). SETTING--Copenhagen and Aarhus, Denmark. SUBJECTS--259 Male members of a Danish homosexual organisation. MAIN OUTCOME MEASURES--Correlations of prevalence and incidence with a wide range of sexual lifestyle variables. RESULTS--Only four (1.6%) subjects were positive for anti-HCV in 1981. The estimated cumulative incidence of positivity for anti-HCV was 4.1% in 1984 (seroconversion rate during 1981-4 (2.5%)) and remained at 4.1% in 1989 (seroconversion rate nil during 1984-9). In contrast, positivity for anti-HBC rose from 44.0% in 1981 to 52.7% in 1984 (seroconversion rate 15.5%) and 58.8% in 1989 (seroconversion rate 12.9%), and that for anti-HIV rose from 8.8% to 24.0% (seroconversion rate 16.7%) and 30.1% (seroconversion rate 8.0%) respectively. Three anti-HCV positive patients seroreverted three to five years later. None of the anti-HCV positive subjects had had a transfusion and only one gave a past history of intravenous drug use. Variables in sexual lifestyle correlated with the presence of anti-HBc but not with that of anti-HCV. CONCLUSIONS--In contrast with hepatitis B virus and HIV, sexual transmission of hepatitis C virus seems to be a rare event. Furthermore, antibodies to the virus may become undetectable after several years. |
| Databáze: | OpenAIRE |
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