Case Report of a Patient with Pseudohypoparathyroidism Associated with Slight Increase in Serum Level of Unconjugated Bilirubin
| Autor: | Shigeto Morimoto, Shoichi Kitano, Atsushi Kamitani, Toshio Ogihara, T Nabata, Shoshi Takamoto, Yoshiyuki Miyashita |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Hemolytic anemia Ineffective erythropoiesis medicine.medical_specialty biology business.industry Crigler–Najjar syndrome Haptoglobin Erythrocyte fragility Parathyroid hormone medicine.disease medicine.disease_cause Endocrinology Parathyroid Hormone Pseudohypoparathyroidism Internal medicine Cyclic AMP medicine biology.protein Humans Abnormality business Hyperbilirubinemia |
| Zdroj: | Folia Endocrinologica Japonica. 66:1148-1157 |
| ISSN: | 0029-0661 |
| Popis: | We treated a 29-year-old male patient with pseudohypoparathyroidism type I, who showed a slight increase in serum indirect bilirubin without any signs of liver dysfunction. Serum levels of total, direct and indirect bilirubins were 2.4, 0.7 and 1.7mg/dl, respectively (normal ranges: 0.2-0.8, 0-0.2 and 0.2-0.6mg/dl, respectively). The cause of the increases in serum bilirubin levels was not clear; however, hemolytic anemia, hereditary unconjugated hyperbilirubinemia or ineffective erythropoiesis were ruled out as causes for the increase, since 1) his serum level of haptoglobin was normal, 2) increase in serum level of indirect bilirubin 120 minutes after the infusion of 50mg nicotinic acid was within the normal range, and 3) severe anemia was not observed. Osmotic fragility of his circulating red blood cells was also within normal range. Three other patients with pseudohypoparathyroidism visiting our clinic also showed slightly high levels of serum indirect bilirubin, although four outpatients with idiopathic hypoparathyroidism showed no such abnormality. Abnormality in the responsiveness to parathyroid hormone and/or to that in the cyclic AMP productivity in this disease may cause the increase in the circulating unconjugated bilirubin. |
| Databáze: | OpenAIRE |
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