COVID-19 associated variations in liver function parameters: a retrospective study
| Autor: | Vikas Suri, Indu Verma, Neha Saini, Pankaj Malhotra, Ram Krishan Saini, Deepy Zohmangaihi, Jyotdeep Kaur, Shiv Lal Soni, Sant Ram, Sadhna Sharma |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Coronavirus disease 2019 (COVID-19) 030204 cardiovascular system & hematology AutoAnalyzer Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine Liver Function Tests law Internal medicine Albumins medicine Humans 030212 general & internal medicine Pandemics Aged Retrospective Studies Liver injury Aged 80 and over medicine.diagnostic_test business.industry SARS-CoV-2 Liver Diseases COVID-19 Retrospective cohort study Bilirubin General Medicine Hepatology Middle Aged medicine.disease Intensive care unit C-Reactive Protein COVID-19 Nucleic Acid Testing Ferritins Female Liver function Liver function tests business Biomarkers |
| Zdroj: | Postgraduate Medical Journal |
| ISSN: | 1469-0756 |
| Popis: | Background Characteristics of laboratory findings of COVID-19 patients are of great significance for diagnosis and treatment. Studies that have analysed the variations in hepatic profile in correlation with the inflammatory markers in SARS-CoV-2 are limited. Methods We retrospectively analysed liver function tests and inflammatory markers of 170 admitted patients with confirmed COVID-19 in the tertiary care centre, Post Graduate Institute of Medical Education and Research (PGIMER), India, using Roche Cobas Autoanalyzer. Results Number of patients with normal liver enzyme levels were 63 (41.5%), while with raised levels of any of the liver enzymes were 89 (58.5%), out of which 43 (48.31%) had liver injury which manifested as increased severity in terms of intensive care unit (ICU) requirement (p=0.0005). Significantly raised levels of liver enzymes and liver injury were observed with age (p Conclusions More than half of patients admitted to the hospital with SARS-CoV-2 infection had an abnormal liver function which was found to be associated with raised levels of inflammatory markers. Significantly higher proportions of patients with abnormal liver function were elderly and males and were at higher risk of progressing to severe disease. |
| Databáze: | OpenAIRE |
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