Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors

Autor:	Benoit Bachand, Dimaio John, M. Arshad Siddiqui
Rok vydání:	1999
Předmět:	Lactams Stereochemistry Peptidomimetic Clinical Biochemistry Thiazolidine Pharmaceutical Science Biochemistry Chemical synthesis Antithrombins Bridged Bicyclo Compounds Structure-Activity Relationship chemistry.chemical_compound Thrombin Drug Discovery polycyclic compounds medicine Structure–activity relationship Molecular Biology Bicyclic molecule Chemistry Organic Chemistry biochemical phenomena metabolism and nutrition Combinatorial chemistry Lactam Molecular Medicine medicine.drug Discovery and development of direct thrombin inhibitors
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 9:913-918
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(99)00130-4
Popis:	A simple and versatile method for preparation of (D)-Phe-Pro peptidomimetic bicyclic thiazolidine lactams is presented. These bicyclic lactams have chemical diversity alpha to the lactam carbonyl and, when linked to electrophilic arginines, provide potent thrombin inhibitors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f13c51116ed8c9011e08e96e3fd0d8 https://doi.org/10.1016/s0960-894x(99)00130-4 Zobrazit plný text záznamu Full Text from ScienceDirect