An approach towards development of monoclonal IgY antibodies against SARS CoV-2 spike protein (S) using phage display method: A review

Autor: Rajeswari Somasundaram, Michael Antonysamy, Ankit Choraria
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Models
Molecular
0301 basic medicine
Phage display
medicine.medical_treatment
Antibody Affinity
Disease
Antibodies
Viral
COVID-19 Testing
0302 clinical medicine
Antibody Specificity
Immunology and Allergy
Spike protein (S)
Mammals
biology
Antibodies
Monoclonal
Egg Yolk
030220 oncology & carcinogenesis
Spike Glycoprotein
Coronavirus
embryonic structures
Monoclonal
RNA
Viral
Antibody
Coronavirus Infections
food.ingredient
Pneumonia
Viral
Immunology
SARS CoV-2
Immunoglobulins
Article
Passive immunotherapy
Betacoronavirus
03 medical and health sciences
food
Species Specificity
Antigen
Yolk
IgY
medicine
Animals
Humans
Pandemics
COVID-19 Serotherapy
Pharmacology
Clinical Laboratory Techniques
SARS-CoV-2
Immunization
Passive
COVID-19
Outbreak
Immunotherapy
Virology
030104 developmental biology
biology.protein
Cell Surface Display Techniques
Chickens
Forecasting
Single-Chain Antibodies
Zdroj: International Immunopharmacology
ISSN: 1567-5769
DOI: 10.1016/j.intimp.2020.106654
Popis: Highlights • Production of highly specific chicken egg yolk (IgY) monoclonal antibodies using phage display method against SARS CoV-2 will be an effective platform which holds much effective clinical and scientific advantages. • This method holds higher specificity, consistency and reproducibility. • Highly scalable manufacturing and lower cross-reactive due to the absence of invariable regions.
The present state of diagnostic and therapeutic developmental race for vaccines against the SARS CoV-2 (nCOVID-19) focuses on prevention and control of this global pandemic which also represents a critical challenge to the global health community. Although development of novel vaccines can prevent the SARS CoV-2 infections, it is still impeded by several other factors and therefore novel approaches towards treatment and management of this disease is the urgent need. Passive immunotherapy plays a vital role as a possible alternative to meet this challenge and among various antibody sources, chicken egg yolk antibodies (IgY) can be used as an alternative to mammalian antibodies which have been previously studied against SARS CoV outbreak in China. In this review, we discuss the strategies for the use of chicken egg yolk (IgY) antibodies in the development of rapid diagnosis and immunotherapy against SARS CoV-2. Also, IgY antibodies have previously been used against various respiratory bacterial and viral infections in humans and animals. Compared to mammalian antibodies (IgG), chicken egg yolk antibodies (IgY) have greater binding affinity to specific antigens, ease of extraction and lower production costs, hence possessing remarkable pathogen-neutralizing activity of pathogens in respiratory and lungs. We provide an overall importance for the use of monoclonal chicken egg yolk antibodies (IgY) using phage display method describing their potential passive immunotherapeutic application for the treatment and prevention of SARS CoV-2 infection which is simple, fast and safe way of approach for treating patients effectively.
Databáze: OpenAIRE
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