Troponin T Percentiles from a Random Population Sample, Emergency Room Patients and Patients with Myocardial Infarction
| Autor: | Michael Fu, Mårten Larsson, Runa Sigurjonsdottir, Per Johanson, Max Petzold, Ola Hammarsten, Lina Said, Bengt Widgren, Kerstin Landin-Wilhelmsen |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Percentile Pediatrics Patients Hospitalized patients Clinical Biochemistry Myocardial Infarction Sensitivity and Specificity Troponin T Troponin complex Internal medicine medicine Humans In patient Myocardial infarction Aged Aged 80 and over Immunoassay business.industry Biochemistry (medical) Dominant factor Middle Aged medicine.disease Cardiology Female Emergency Service Hospital business Random population |
| Zdroj: | Clinical Chemistry. 58:628-637 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1373/clinchem.2011.171496 |
| Popis: | BACKGROUND High-sensitivity cardiac troponin T (cTnT) assays detect small clinically important myocardial infarctions (MI) but also yield higher rates of false-positive results owing to increased concentrations sometimes present in patients without MI. Better understanding is needed of factors influencing the 99th percentile of cTnT concentrations across populations and the frequency of changes in cTnT concentrations >20% often used in combination with increased cTnT concentrations for diagnosis of MI. METHODS cTnT percentiles were determined by use of the Elecsys® hscTnT immunoassay (Modular® Analytics E170) in a random population sample, in emergency room (ER) patients, and in patients with non–ST-elevation MI (NSTEMI). Changes in cTnT concentrations were determined in hospitalized patients without MI. RESULTS The 99th cTnT percentile in a random population sample (median age, 65 years) was 24 ng/L. In ER patients 65 years old it was 82 ng/L and highly age dependent. In hospitalized patients without MI the 97.5th percentile for change in the cTnT concentration was 51%–67%. cTnT remained below the 99th percentile (12 ng/L) in 1% of patients with NSTEMI until 8.5 h after symptom onset and 6 h after ER arrival. CONCLUSIONS Age >65 years was the dominant factor associated with increased cTnT in ER patients. This age association was more prominent in ER patients than in a random population sample. Changes in serial cTnT concentrations >20% were common in hospitalized patients without MI. |
| Databáze: | OpenAIRE |
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