In vivo electric conductivity of cervical cancer patients based on B1 + maps at 3T MRI
| Autor: | P. A. J. De Boer, A J Nederveen, C.A.T. Van den Berg, Rob Remis, Lukas J.A. Stalpers, Edmond Balidemaj, A.L.H.M.W. Van Lier, G. H. Westerveld, Johannes Crezee |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Hyperthermia
Pathology medicine.medical_specialty Materials science EPT Conductivity Research Support 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine In vivo medicine Journal Article Radiology Nuclear Medicine and imaging Non-U.S. Gov't Cervical cancer medicine.diagnostic_test electrical conductivity Radiological and Ultrasound Technology Research Support Non-U.S. Gov't Specific absorption rate Magnetic resonance imaging medicine.disease hyperthermia dielectric properties Radiology Nuclear Medicine and imaging 030220 oncology & carcinogenesis Tomography conductivity Ex vivo Biomedical engineering |
| Zdroj: | Physics in Medicine and Biology, 61(4), 1596. IOP Publishing Ltd. |
| ISSN: | 0031-9155 |
| Popis: | The in vivo electric conductivity (σ) values of tissue are essential for accurate electromagnetic simulations and specific absorption rate (SAR) assessment for applications such as thermal dose computations in hyperthermia. Currently used σ-values are mostly based on ex vivo measurements. In this study the conductivity of human muscle, bladder content and cervical tumors is acquired non-invasively in vivo using MRI. The conductivity of 20 cervical cancer patients was measured with the MR-based electric properties tomography method on a standard 3T MRI system. The average in vivo σ-value of muscle is 14% higher than currently used in human simulation models. The σ-value of bladder content is an order of magnitude higher than the value for bladder wall tissue that is used for the complete bladder in many models. Our findings are confirmed by various in vivo animal studies from the literature. In cervical tumors, the observed average conductivity was 13% higher than the literature value reported for cervical tissue. Considerable deviations were found for the electrical conductivity observed in this study and the commonly used values for SAR assessment, emphasizing the importance of acquiring in vivo conductivity for more accurate SAR assessment in various applications. |
| Databáze: | OpenAIRE |
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