The in vitro and in vivo effect of recombinant interferon α-2a on circulating haemopoietic progenitors in polycythaemia vera
| Autor: | Cerruti A, Castello G, Roberto Lerza, D. Cavallini, Ivo Pannacciulli, Giuseppe Bogliolo |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Polycythaemia Alpha interferon Spleen Interferon alpha-2 Pharmacology Myeloproliferative Disorders Polycythemia vera In vivo medicine Humans Progenitor cell Polycythemia Vera Erythroid Precursor Cells Aged business.industry Macrophages Interferon-alpha Hematology Middle Aged Hematopoietic Stem Cells medicine.disease Recombinant Proteins medicine.anatomical_structure Immunology business Granulocytes |
| Zdroj: | British Journal of Haematology. 87:621-623 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1994.tb08324.x |
| Popis: | In four patients with polycythaemia vera (PV) who received interferon alpha (IFN-alpha) (3 MU subcutaneously three times a week) for 5 months, peripheral blood levels of granulocyte-macrophage colony-forming units and erythroid burst-forming units were assessed monthly. Circulating progenitors significantly decreased throughout the treatment period. Moreover, we observed an inhibitory activity of IFN-alpha on haemopoietic progenitor cells (HPC) from patients with PV in vitro. The data presented confirm previous research which has shown an inhibitory effect of IFN-alpha on HPC from patients with myeloproliferative disorders. Significant improvement in the patients' clinical and haematological conditions should encourage larger studies on IFN-alpha administration in PV patients. |
| Databáze: | OpenAIRE |
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