Chromosome translocation and c-MYC activation by Epstein-Barr virus and Euphorbia tirucalli in B lymphocytes
| Autor: | Tsuneyuki Oikawa, T. Kinoshita, Takao Aya, Fumio Mizuno, Noboru Kuzumaki, Shigeki Koizumi, Toyoro Osato, Koichi Koshimizu, Chiharu Satoh, Hajime Ohigashi, Shosuke Imai |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Herpesvirus 4 Human Euphorbia tirucalli Chromosomal translocation medicine.disease_cause Virus Translocation Genetic Proto-Oncogene Proteins c-myc hemic and lymphatic diseases Phorbol Esters medicine Humans B-Lymphocytes Plants Medicinal biology Cytogenetics Chromosome General Medicine Environmental Exposure medicine.disease biology.organism_classification Epstein–Barr virus Virology Burkitt Lymphoma In vitro Lymphoma Chromosomes Human Pair 8 |
| Zdroj: | Lancet (London, England). 337(8751) |
| ISSN: | 0140-6736 |
| Popis: | Dual exposure to Epstein-Barr virus and purified 4-deoxyphorbol ester derived from the plant Euphorbia tirucalli induced a high frequency of chromosomal rearrangements in human B lymphocytes in vitro. Rearrangements most commonly affected chromosome 8, the chromosome most often showing structural changes in Burkitt's lymphoma (BL) cells. E tirucalli is indigenous in parts of Africa where BL is endemic and may be an important risk factor for the disease. |
| Databáze: | OpenAIRE |
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