Immunogenetics of early-onset insulin-dependent diabetes mellitus among the Japanese: HLA, Gm, BF, GLO, and organ-specific autoantibodies — the J.D.S. study
| Autor: | Teruo Kitagawa, Keiji Murakami, Isamu Tuchida, Tomio Jinnouchi, Takayoshi Toyota, Shigeo Aono, Hideshi Kuzuya, Itsuro Hibi, Tetsuro Kobayashi, Yoshio Ikeda, Kaichi Kida, Hiroaki Nishimukai, Kunihiro Doi, Nobuo Matsuura, Goro Mimura |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Erythrocytes
Genotype Endocrinology Diabetes and Metabolism Thyroid Gland Lyases Human leukocyte antigen Immunogenetics Thyroglobulin Endocrinology Immunoglobulin Gm Allotypes Japan HLA Antigens Reference Values Microsomes Diabetes mellitus Internal Medicine medicine Humans Autoantibodies Enzyme Precursors biology business.industry Haplotype Lactoylglutathione Lyase Autoantibody General Medicine medicine.disease Phenotype Diabetes Mellitus Type 1 Immunology biology.protein Antibody business Complement Factor B |
| Zdroj: | Diabetes Research and Clinical Practice. 8:253-262 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/0168-8227(90)90124-c |
| Popis: | The Japan Diabetes Society (JDS) conducted a multicenter study on the immunogenetics of early-onset insulin-dependent diabetes mellitus (IDDM) of the Japanese. Human leukocyte antigen (HLA), properdin factor B (BF), immunoglobulin heavy-chain complex (Gm), and glyoxalase of erythrocytes (GLO) were typed, and organ-specific autoantibodies, including islet cell antibody (ICA), were assayed in 159 Japanese IDDM patients and their family members and in 258 healthy Japanese controls. The HLA-DRw9 phenotype and HLA-Bw61/DRw9 haplotype were significantly increased among the patients with autoantibodies other than ICA but with no autoimmune diseases (RR = 5.84, cP less than 0.001; and RR = 7.45, P less than 0.001), whereas the HLA-DR4 phenotype and HLA-Bw54/DR4 haplotype were significantly increased in those without either the autoantibodies or autoimmune diseases (RR = 2.64, cP less than 0.001; and RR = 4.55, P less than 0.001). The HLA-DR4 phenotype was significantly increased in the patients with autoimmune thyroid diseases (RR = 6.21, cP less than 0.05). In all groups of patients, the HLA-DR2 phenotype was significantly decreased, and the relative risk of the HLA-DRw9/DR4 genotype was highest among all HLA-DR genotypes. No significant association was found between HLA type and the duration or incidence of ICA. Gm types of g and gft were significantly increased in the patients with the autoantibodies (RR = 2.11, P less than 0.05; and RR = 34.11, P less than 0.05), whereas the BF-F phenotype was significantly decreased in the patients either with or without autoantibodies (RR = 0.43, P less than 0.05; and RR = 0.46, P less than 0.05). There was no association between IDDM and GLO type. These data indicate that immunogenetic bases underlying IDDM of the Japanese are heterogeneous, as are those in Caucasians. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|