Effects of Rhinovirus-Induced Common Colds on Granulocyte Activity in Allergic Rhinitis
| Autor: | I Ener, Per Venge, Lennart Greiff, Steven H. Myint, Margareta Linden, Morgan Andersson, C. G. A. Persson |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Microbiology (medical) Allergy Eosinophil Peroxidase Rhinovirus Neutrophils Common Cold Tryptase medicine.disease_cause Allergen otorhinolaryngologic diseases medicine Humans Eosinophil degranulation Mast Cells Administration Intranasal Peroxidase biology business.industry Serine Endopeptidases Rhinitis Allergic Seasonal Allergens respiratory system medicine.disease Mast cell respiratory tract diseases Enzyme Activation Eosinophils Infectious Diseases medicine.anatomical_structure Peroxidases Immunology biology.protein Female Tryptases Nasal Lavage Fluid business Eosinophil peroxidase Granulocytes |
| Zdroj: | Journal of Infection. 45:227-232 |
| ISSN: | 0163-4453 |
| DOI: | 10.1053/jinf.2002.1063 |
| Popis: | Objective: To explore the activities of mast cells, eosinophils, and neutrophils in patients with allergic rhinitis developing common colds and increased responsiveness to allergen following nasal rhinovirus inoculation. Methods: We have revisited a nasal lavage material obtained from 17 patients who were successfully inoculated with rhinovirus outside the pollen season and received nasal allergen challenges before and after inoculation. We have examined indices of mast cell activity (tryptase), eosinophil degranulation (eosinophil peroxidase; EPO), and neutrophil activation (myeloperoxidase; MPO). Results: Allergen challenges performed before rhinovirus inoculation increased the nasal output of EPO. Notably, this response was significantly greater after rhinovirus inoculation (cf. before inoculation). The output of MPO was also increased following allergen challenge after, but not before, rhinovirus inoculation. Nasal lavage fluid levels of tryptase were increased following allergen challenge similarly before and after rhinovirus inoculation. Also, the viral infection did not affect the baseline levels of tryptase. Conclusions: The present data demonstrate that rhinovirus infections activate both eosinophils and neutrophils, but that they may not affect mast cell activity. We suggest that common colds in part through stimulation of granulocyte activity potentiate the airway inflammation in allergic diseases. |
| Databáze: | OpenAIRE |
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