Distinct IA-2 autoantibody epitope recognition between childhood-onset and adult-onset type 1 diabetes
| Autor: | Takahiro Abe, Kenichi Yamakawa, Yoshihiko Yamaguchi, Masako Ozaki, Katsumi Eguchi, Norio Abiru, Hironori Yamasaki, Mikako Yamauchi, Shigeo Uotani, Eiji Kawasaki, Yasunori Sera |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment IA-2-autoantibody General Biochemistry Genetics and Molecular Biology Epitope Epitopes History and Philosophy of Science Antibody Specificity Internal medicine Diabetes mellitus medicine Humans Insulin Age of Onset Child Autoantibodies chemistry.chemical_classification Type 1 diabetes business.industry Glutamate Decarboxylase General Neuroscience Autoantibody Middle Aged medicine.disease In vitro Amino acid Isoenzymes Endocrinology Diabetes Mellitus Type 1 chemistry Diabetes Mellitus Type 2 Immunology Female business |
| Zdroj: | Annals of the New York Academy of Sciences. 958 |
| ISSN: | 0077-8923 |
| Popis: | Different autoimmune mechanisms may be involved in childhood- and adult-onset type 1 diabetes. Our aim was to explore the differences in IA-2 autoantibody epitope recognition between childhood- and adult-onset type 1 diabetes. Therefore, in vitro synthesized radiolabeled IA-2ic (amino acid 601-979), IA-2JM (amino acid 557-629), and IA-2PTP (amino acid 630-979) were used to analyze the IA-2 autoantibody epitope specificities in 93 patients with new-onset type 1 diabetes. Among 93 patients with type 1 diabetes the prevalences of autoantibodies to GAD, IA-2ic, and insulin were 69.9%, 58.1%, and 45.2%, respectively. The prevalence of IA-2ic autoantibodies in patients with childhood-onset type 1 diabetes (aged |
| Databáze: | OpenAIRE |
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