Influence of zinc, D-penicillamine and oxygen on poisoning withAmanita phalloides. Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom
| Autor: | L. Bianchi, N. K. Chiodetti, G. L. Floersheim, A. Probst, C. G. Honegger |
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| Rok vydání: | 1984 |
| Předmět: |
Amanita
medicine.medical_specialty Necrosis Dopamine Immunology chemistry.chemical_element Mushroom Poisoning Zinc Toxicology Median lethal dose Lethal Dose 50 Mice Norepinephrine Internal medicine medicine Animals Pharmacology (medical) Amanita phalloides Brain Chemistry Pharmacology biology Penicillamine Oxygen Inhalation Therapy biology.organism_classification Liver regeneration Liver Regeneration Endocrinology Liver chemistry Catecholamine Female medicine.symptom medicine.drug |
| Zdroj: | Agents and Actions. 14:124-130 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01966845 |
| Popis: | Pretreatment with zinc aspartate increased the survival rate of mice poisoned with a lyophilisate from the mushroom Amanita phalloides (APL). In the livers of the zinc-treated animals, confluent necrosis was cleared earlier. Zinc also prevented the reduction of brain noradrenaline caused by the mushroom as well as the rise of brain dopamine and brain weight. D-Penicillamine also protected against the lethal effects of APL. The survival afforded by zinc pretreatment was marginally ameliorated by additional oxygenation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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