Lung Dose for Minimally Moving Thoracic Lesions Treated With Respiration Gating
| Autor: | F Lerma, Jose Penagaricano, Mirek Fatyga, Ivaylo B. Mihaylov, Eduardo G. Moros |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Respiratory-Gated Imaging Techniques
Cancer Research Lung Neoplasms Movement medicine.medical_treatment Gating medicine Humans Radiology Nuclear Medicine and imaging Four-Dimensional Computed Tomography Respiratory system Radiation Injuries Radiation treatment planning Lung cancer Lung Retrospective Studies Radiation business.industry Radiotherapy Planning Computer-Assisted Respiratory disease Heart Radiotherapy Dosage medicine.disease Radiation therapy medicine.anatomical_structure Inhalation Spinal Cord Oncology Exhalation Breathing Radiotherapy Intensity-Modulated business Nuclear medicine |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 77:285-291 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2009.08.021 |
| Popis: | Purpose: To evaluate incidental doses to benign lung tissue for patients with minimally moving lung lesions treated with respiratory gating. Methods and Materials: Seventeen lung patient plans were studied retrospectively. Tumor motion was less than 5 mm in all cases. For each patient, mid-ventilation (MidVen) and mid-inhalation (MidInh) breathing phases were reconstructed. The MidInh phase was centered on the end-of-inhale (EOI) phase within a 30% gating window. Planning target volumes, heart, and spinal cord were delineated on the MidVen phase and transferred to the MidInh phase. Lungs were contoured separately on each phase. Intensity-modulated radiotherapy plans were generated on the MidVen phases. The plans were transferred to the MidInh phase, and doses were recomputed. The evaluation metric was based on dose indices, volume indices, generalized equivalent uniform doses, and mass indices for targets and critical structures. Statistical tests were used to establish the significance of the differences between the reference (MidVen) and compared (MidInh) dose distributions. Results: Statistical tests demonstrated that the indices evaluated for targets, cord, and heart differed by within 2.3%. The index differences in the lungs, however, are in excess of 6%, indicating the potentially achievable lung sparing and/or dose escalation. Conclusions: Respiratory gating isaclinical optionfor patientswith minimally moving lunglesions treated at EOI. Gating will be more beneficial for larger tumors, since dose escalation in those cases will result in a larger increase in the tumor control probability. 2010 Elsevier Inc. Gating, 4D, Dose, IMRT, Lung, Motion management. |
| Databáze: | OpenAIRE |
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