Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial
| Autor: | Sedighah Akhavan Karbasi, Fariba Binesh, Razieh Fallah, Saeideh Sabbaghzadegan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Abdominal pain Vomiting Endocrinology Diabetes and Metabolism Nutritional Status Iran Placebo Gastroenterology Seizures Febrile Shahid Heartburn Recurrence Reference Values Internal medicine Febrile seizure medicine Humans Adverse effect Nutrition and Dietetics business.industry Infant medicine.disease Zinc Sulfate Confidence interval Abdominal Pain Trace Elements Zinc Treatment Outcome Child Preschool Anesthesia Dietary Supplements Female medicine.symptom business |
| Zdroj: | Nutrition. 31:1358-1361 |
| ISSN: | 0899-9007 |
| DOI: | 10.1016/j.nut.2015.05.024 |
| Popis: | Objective Serum zinc level might be related to pathogenesis of febrile seizure (FS). The purpose of this study was to evaluate efficacy and safety of oral zinc supplementation on FS recurrence prevention in non-zinc-deficient children. Materials and Methods In a randomized clinical study, one hundred 18 to 60 mo old children with normal zinc level with first simple FS were referred to Shahid Sadoughi Hospital, Yazd, Iran from May 2012 to June 2013, were randomly assigned to two groups to receive 2 mg/kg/d zinc sulfate for six consecutive months or placebo as control group and were followed up for 1 y for FS recurrence. Results 41 girls and 59 boys with mean age of 2.47 ± 1.01 y were evaluated. Race, mean weight, height and body fat were similar in both groups. FS recurrence occurred in 19 children (38%) in the control group [95% confidence interval (CI): 19.45%–53.95%] and in 11 children (22%) in the zinc sulfate (95% CI: 57.47%–89.13%) groups, respectively; and the zinc group had lower FS recurrence ( P = 0.03). The mean serum zinc level before intervention was lower in children with FS recurrence (72.43 ± 14.58 μg/dL versus 96.33 ± 12.69 μg/dL, P = 0.04). Gastrointestinal side effects (vomiting in five children, heartburn in two children and abdominal pain in one child) were seen in 16% of the zinc group and vomiting occurred in two children (4%) in control group and frequency of adverse events was similar in the two groups ( P = 0.1). Conclusion Zinc supplementation should be considered as effective and safe in prevention of FS recurrence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect