Age-dependent effect of plasma nitric oxide on parasite density in Ghanaian children with severe malaria
| Autor: | Frank P. Mockenhaupt, Andreas K. Nussler, Ekkehart Dietz, Philipp Zanger, Sabine Gellert, Jana Burkhardt, Jakob P. Cramer, Rowland N. Otchwemah, Stephan Ehrhardt, Ulrich Bienzle |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Genotype Anemia Plasmodium falciparum Population Malaria Cerebral Nitric Oxide Synthase Type II Biology Nitric Oxide Ghana Nitric oxide chemistry.chemical_compound parasitic diseases Blood plasma medicine Animals Humans Malaria Falciparum Child Promoter Regions Genetic education Parasite Egg Count Nitrites education.field_of_study Nitrates Polymorphism Genetic S-Nitrosothiols Age Factors Public Health Environmental and Occupational Health Infant medicine.disease biology.organism_classification Nitric oxide synthase Infectious Diseases chemistry Cerebral Malaria Child Preschool Immunology biology.protein Female Parasitology Nitric Oxide Synthase Malaria |
| Zdroj: | Tropical Medicine and International Health. 10:672-680 |
| ISSN: | 1365-3156 1360-2276 |
| Popis: | Summary Nitric oxide (NO) has toxic properties against Plasmodium falciparum. While high blood levels have been associated with protection against severe malarial disease, they may also contribute to the pathophysiology of cerebral malaria and severe anaemia. Promoter variants in the inducible nitric oxide synthase (iNOS) gene have been shown to influence NO concentrations and disease manifestation. However, findings are conflicting. We examined associations of plasma NO metabolites (NOx) with symptoms of severe malaria, particularly malarial anaemia and cerebral malaria, and with iNOS promoter variants. In 210 Ghanaian children with severe malaria, we measured plasma nitrite, nitrate, and S-nitrosothiol, and genotyped the iNOS promoter variants )954G fi C, )1173C fi T, and the )2.5 kb (CCTTT)n microsatellite. NOx levels decreased with age. In young children ( |
| Databáze: | OpenAIRE |
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