Additional file 1 of Effects of BNT162b2 mRNA vaccine on COVID-19 infection and hospitalisation amongst older people: matched case control study for England

Autor: Mason, Thomas F. D., Whitston, Matt, Hodgson, Jack, Watkinson, Ruth E., Lau, Yiu-Shing, Abdulrazeg, Omnia, Sutton, Matt
Rok vydání: 2021
DOI: 10.6084/m9.figshare.16829323
Popis: Additional file 1: Appendix 1: Data sources. Appendix 2: Matching and adjustment methodology: Table A2-1 - Summary of the change in the number and COVID-19 status of people available for matching to vaccinated individuals as the monitoring period used in the evaluation is extended. Figure A2-1 - Numbers of individuals testing positive for COVID-19 post vaccination with a comparison to their match pairs as a rate per 100,000 pre and post adjustment. Appendix 3: Measuring COVID-19 related emergency hospital attendances and admissions: Table A3-1 - List of clinical codes used to identify first COVID-19 related ED attendances and hospital admissions. Figure A3-1 - Delay between specimen data for a COVID-19 positive test and the associated ED (A&E) attendance. Figure A3-2 - Counts of COVID-19 related ED (A&E) attendances and admissions by method of identification, for (a) attendances, and (b) admissions. Appendix 4: Changing composition of the study population by follow-up period: Table A4-1 - Demographic and clinical characteristics of vaccinated persons and their unvaccinated controls. Appendix 5: Comparison of vaccinated and unvaccinated controls pre-vaccination programme: Table A5-1. Adjusted odds ratios generated using a logistic regression model to predict test positivity between days 14 and 41 post vaccination event for vaccinated individuals and their pairwise controls. Figure A5-1 - Comparison of the use of hospital-based services per day for the vaccinated and the unvaccinated pairwise control group. Figure A5-2 - Comparison of the number of negative COVID-19 tests by specimen date for the vaccinated group and unvaccinated control. Appendix 6: Sensitivity of outcomes to control selection: Figure A6-1 - Percentage difference in positive COVID-19 tests, ED (A&E) attendances with COVID-19, hospital admission with COVID-19 for six matching strategies by day since first vaccine dose. Table A6-1 - Comparison of estimates of the effectiveness of the BNT162b2 mRNA Covid-19 vaccine by days since vaccination for six matching strategies. References for supporting appendices
Databáze: OpenAIRE