Prevalence of Thalassemia and Glucose-6-Phosphate Dehydrogenase Deficiency in Newborns and Adults at the Ramathibodi Hospital, Bangkok, Thailand

Autor:	Wansa Banyatsuppasin, Sumalee Jindadamrongwech, Punnee Butthep, Anchalee Limrungsikul
Rok vydání:	2017
Předmět:	0301 basic medicine Adult Male congenital hereditary and neonatal diseases and abnormalities Thalassemia Clinical Biochemistry Physiology Dehydrogenase 03 medical and health sciences hemic and lymphatic diseases parasitic diseases medicine Prevalence Humans Genetics (clinical) business.industry Biochemistry (medical) Infant Newborn Hematology medicine.disease Thailand 030104 developmental biology Blood Disorder Glucosephosphate Dehydrogenase Deficiency Mutation Female business Malaria Glucose-6-phosphate dehydrogenase deficiency
Zdroj:	Hemoglobin. 41(4-6)
ISSN:	1532-432X
Popis:	Thalassemias and glucose-6-phosphate dehydrogenase (G6PD) deficiency are the most common inherited blood disorders. They are distributed among populations living in malaria endemic regions resulting in survival advantage from severe malaria disease. The aims of this study were to analyze the prevalence of thalassemias and G6PD deficiency at the Ramathibodi Hospital, Bangkok, Thailand. A total of 616 adult and 174 cord blood samples were collected and analyzed for red blood cell (RBC) parameters, hemoglobin (Hb) typing and DNA analysis for G6PD mutations and α-thalassemia (α-thal). The two most prominent types of thalassemia were heterozygous Hb E (HBB: c.79GA), (19.5% in newborns and 35.6% in adults) followed by heterozygous α-thal-2 [-α
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e92943a3fce9f2b85ca9acc5f434e88f https://pubmed.ncbi.nlm.nih.gov/29251006 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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