Treatment of Non-tuberculous Mycobacterial Infections in Patients without AIDS
| Autor: | Nadja Heurlin, Björn Petrini |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Adolescent medicine.medical_treatment Disease Acquired immunodeficiency syndrome (AIDS) Internal medicine Humans Medicine Disseminated disease Child Sida Antibiotics Antitubercular Aged Aged 80 and over Mycobacterium Infections Chemotherapy General Immunology and Microbiology biology business.industry Respiratory disease General Medicine Middle Aged medicine.disease biology.organism_classification Surgery Chronic infection Aminoglycosides Treatment Outcome Infectious Diseases Rifabutin Female Viral disease business Ethambutol Follow-Up Studies |
| Zdroj: | Scandinavian Journal of Infectious Diseases. 25:619-623 |
| ISSN: | 1651-1980 0036-5548 |
| DOI: | 10.3109/00365549309008551 |
| Popis: | This report summarizes the results of an 8-year study of the treatment of non-tuberculous mycobacterial infections and the long-term efficacy of this treatment in patients without AIDS. Of 25 patients, aged 10-82 years, 24 had pulmonary involvement; in 5 cases as part of disseminated disease. One patient had a renal infection only. Predisposing factors were identified in 16 patients. M. avium-intracellulare and M. malmoense were isolated in 17 and 7 patients, respectively, and M. kansasii in 1 patient. Three patients were subjected to lobectomy and 22 received multiple drug chemotherapy for 18-60 months. Chemotherapy was initially effective in 17/22 patients and surgery in 3/3. However, in the end 10 patients died of their mycobacterial infection, and 6 are still suffering from chronic infection. Only 7 patients appear to be free of disease more than 2 years after completing chemotherapy. |
| Databáze: | OpenAIRE |
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