Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity
| Autor: | T. P. Storozhevykh, L. A. Andreeva, Pinelis Vg, Ya. E. Senilova, N. F. Myasoyedov, G. R. Tukhbatova |
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| Rok vydání: | 2007 |
| Předmět: |
Proline
Cell Survival Semax Glutamic Acid chemistry.chemical_element Mitochondrion Pharmacology Calcium Biology Neuroprotection General Biochemistry Genetics and Molecular Biology Calcium in biology Adrenocorticotropic Hormone medicine Animals Homeostasis Rats Wistar Neurons Calcium metabolism Glutamate receptor Neurotoxicity General Medicine medicine.disease Peptide Fragments Rats Cell biology chemistry Oligopeptides medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 143:601-604 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-007-0192-x |
| Popis: | Semax (100 microM) and its Pro-Gly-Pro fragment (20 and 100 microM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells under conditions of glutamate neurotoxicity. Incubation with these peptides improved neuronal survival by on average 30%. The neuroprotective effect of semax in cerebral ischemia/hypoxia can be due to improvement of mitochondrial resistance to "calcium" stress. |
| Databáze: | OpenAIRE |
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