Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing
| Autor: | Christoph K. Moeller, Marlies Knipper, Ulrike Zimmermann, Winfried Neuhuber, Lukas Rüttiger, Matthias Sausbier, Harald van Straaten, Niels Brandt, Holger Schulze, Simone Kurt, Jennifer Kindler, Jutta Engel, Ulrike Sausbier, Peter Ruth |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Inferior colliculus
medicine.medical_specialty BK channel Protein subunit Audiology Biology Biochemistry Germline Research Communications inferior colliculus Mice 03 medical and health sciences 0302 clinical medicine Hearing Cochlear hair cell Hair Cells Auditory otorhinolaryngologic diseases Genetics medicine hair cell-specific BK channel-knockout mice Animals Learning Large-Conductance Calcium-Activated Potassium Channels Molecular Biology Cochlea 030304 developmental biology Mice Knockout 0303 health sciences in vivo electrophysiology Dynamic range discrimination learning Brain Immunohistochemistry biology.protein sense organs Neuroscience 030217 neurology & neurosurgery Biotechnology Coding (social sciences) |
| Zdroj: | The FASEB Journal |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fj.11-200535 |
| Popis: | Large conductance, voltage- and Ca2+-activated K+ (BK) channels in inner hair cells (IHCs) of the cochlea are essential for hearing. However, germline deletion of BKα, the pore-forming subunit KCNMA1 of the BK channel, surprisingly did not affect hearing thresholds in the first postnatal weeks, even though altered IHC membrane time constants, decreased IHC receptor potential alternating current/direct current ratio, and impaired spike timing of auditory fibers were reported in these mice. To investigate the role of IHC BK channels for central auditory processing, we generated a conditional mouse model with hair cell-specific deletion of BKα from postnatal day 10 onward. This had an unexpected effect on temporal coding in the central auditory system: neuronal single and multiunit responses in the inferior colliculus showed higher excitability and greater precision of temporal coding that may be linked to the improved discrimination of temporally modulated sounds observed in behavioral training. The higher precision of temporal coding, however, was restricted to slower modulations of sound and reduced stimulus-driven activity. This suggests a diminished dynamic range of stimulus coding that is expected to impair signal detection in noise. Thus, BK channels in IHCs are crucial for central coding of the temporal fine structure of sound and for detection of signals in a noisy environment.—Kurt, S., Sausbier, M., Rüttiger, L., Brandt, N., Moeller, C. K., Kindler, J., Sausbier, U., Zimmermann, U., van Straaten, H., Neuhuber, W., Engel, J., Knipper, M., Ruth, P., Schulze, H. Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text