Liver prometastatic reaction: Stimulating factors and responsive cancer phenotypes
| Autor: | Eduardo M. Sotomayor, Cira R. García de Durango, Thierry Vilboux, Olatz Crende, Alejandro Herreros-Pomares, Benedetto Ielpo, Sandra López-Doménech, R. Caruso, Fernando Vidal-Vanaclocha, Antonio Gil, Emilio Vicente, Alvaro Gonzalez, Fernando Lapuente, Yolanda Quijano, Eva Ruiz-Casares, Hipolito Duran, Leticia Vidal-Lartitegui |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research Stromal cell Colorectal cancer Context (language use) 03 medical and health sciences 0302 clinical medicine Circulating tumor cell medicine Tumor Microenvironment Animals Humans Tumor microenvironment business.industry Melanoma Liver Neoplasms Cancer medicine.disease Neoplastic Cells Circulating Primary tumor 030104 developmental biology Phenotype 030220 oncology & carcinogenesis Cancer research Neoplasm Recurrence Local business |
| Zdroj: | Seminars in cancer biology. 71 |
| ISSN: | 1096-3650 |
| Popis: | Cancer is first a localized tissue disorder, whose soluble and exosomal molecules and invasive cells induce a host response providing the stromal components of the primary tumor microenvironment (TME). Once the TME is developed, cancer-derived molecules and cells can more efficiently spread out and a whole-body response takes place, whose pathophysiological changes may result in a paraneoplastic syndrome. Remote organ-specific prometastatic reactions may also occur at this time, facilitating metastatic activities of circulating tumor cells (CTCs) through premetastatic niche development at targeted organs. However, additional signaling factors from the inter-organ communication network involved in the pathophysiology and comorbidities of cancer patients may also regulate prometastatic reaction-stimulating effects of cancer and non-cancer tissue factors. This article provides a conceptual overview of our ongoing clinical research on the liver prometastatic reaction (LPR) of patients with colorectal cancer (CRC), their portal vein- and hepatic artery-driven LPR-Stimulating Factors (LPR-SF), and their resulting LPR-derived Metastasis-Stimulating Factors (LPR-MSF) acting on liver-invading CRC cells. In addition, we also provide new insights on the molecular subtyping of LPR-responsive cancer phenotypes in patients with CRC and melanoma; and on how to investigate and interpret the prometastatic infrastructure in the real pathophysiological context of patients with cancer undergoing surgical procedures and receiving pharmacological treatments with multiple side effects, including those affecting the LPR, its stimulating factors and responsive cancer phenotypes. |
| Databáze: | OpenAIRE |
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