Statin Therapy, LDL Cholesterol, C-Reactive Protein, and Coronary Artery Disease
| Autor: | Charles O'Shaughnessy, Tim Crowe, E. Murat Tuzcu, John Orazem, Steven E. Nissen, John Tsai, Raymond D. Magorien, William J. Sasiela, Paul Schoenhagen, Peter Ganz |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Atorvastatin Myocardial Infarction Coronary Artery Disease Gastroenterology Coronary artery disease chemistry.chemical_compound Risk Factors Internal medicine Secondary Prevention Humans Medicine Pyrroles Ultrasonography Interventional Pravastatin Univariate analysis biology business.industry Cholesterol Anticholesteremic Agents C-reactive protein Cholesterol LDL General Medicine Middle Aged medicine.disease Coronary Vessels Lipids C-Reactive Protein Endocrinology chemistry Heptanoic Acids Disease Progression biology.protein Regression Analysis Female lipids (amino acids peptides and proteins) Hydroxymethylglutaryl-CoA Reductase Inhibitors business Biomarkers medicine.drug Lipoprotein |
| Zdroj: | New England Journal of Medicine. 352:29-38 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejmoa042000 |
| Popis: | background Recent trials have demonstrated better outcomes with intensive than with moderate statin treatment. Intensive treatment produced greater reductions in both low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP), suggesting a relationship between these two biomarkers and disease progression. methods We performed intravascular ultrasonography in 502 patients with angiographically documented coronary disease. Patients were randomly assigned to receive moderate treatment (40 mg of pravastatin orally per day) or intensive treatment (80 mg of atorvastatin orally per day). Ultrasonography was repeated after 18 months to measure the progression of atherosclerosis. Lipoprotein and CRP levels were measured at baseline and follow-up. results In the group as a whole, the mean LDL cholesterol level was reduced from 150.2 mg per deciliter (3.88 mmol per liter) at baseline to 94.5 mg per deciliter (2.44 mmol per liter) at 18 months (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|