Spinal Manifestation of Metastasizing Leiomyosarcoma
| Autor: | C. Alexiadou-Rudolf, K. Nanassis, Philippos Tsitsopoulos |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Leiomyosarcoma
medicine.medical_specialty medicine.medical_treatment Thoracic Vertebrae Spinal cord compression Biomarkers Tumor medicine Humans Orthopedics and Sports Medicine Uterine Neoplasm Spinal Neoplasms Hysterectomy business.industry Middle Aged Decompression Surgical medicine.disease Immunohistochemistry Magnetic Resonance Imaging Primary tumor Surgery body regions medicine.anatomical_structure Leiomyoma Uterine Neoplasms Thoracic vertebrae Female Neurology (clinical) business Paraplegia |
| Zdroj: | Spine. 24:987-990 |
| ISSN: | 0362-2436 |
| DOI: | 10.1097/00007632-199905150-00011 |
| Popis: | Study Design. Case report. Objective. To Drovide additional information on possible relations between uterine and spinal manifestations of leiomyosarcoma. of Background Data. Spinal metastases and primary spinal manifestation of leiomyosarcoma and other malignant smooth muscle tumors are rarely observed. Methods. Clinical and radiologic follow-up of a patient with a spinal tumor. Results. A 46-year-old women had rapidly progressive paraplegia caused by an extramedullary lesion in the extradural space at T2-T3, with spinal cord compression. After surgical decompression, the resected tumor was histologically classified as a leiomyosarcoma. Diagnostic work-up failed to detect the primary tumor site. Previous medical history had been uneventful except for hysterectomy 3 years earlier for a leiomyoma. Extended necroses and focal metaplasia were already described in the hysterectomy specimen indicating malignant disease; however, it was not definitely diagnosed. Multiple leiomyosarcoma metastases developed 22 months later. Conclusions. In retrospect, the origin of the leiomyosarcoma that manifested in the thoracic spine of the patient must be reconsidered. Rather than a primary dural leiomyosarcoma, this tumor represented the first evidence of recurrence of a missed diagnosis of early-stage uterine leiomyosarcoma. |
| Databáze: | OpenAIRE |
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