The Effect of Strict Control with the Artificial β-Cell on Plasma Lipid Levels in Insulin-Dependent Diabetes
| Autor: | Asmal Ac, Thomas T. Aoki, Om P. Ganda, Vlachokosta Fv |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment chemistry.chemical_compound Insulin Infusion Systems Internal medicine Diabetes mellitus Plasma lipids Diabetes Mellitus Internal Medicine medicine Humans Triglycerides Glycated Hemoglobin Advanced and Specialized Nursing Cholesterol business.industry Insulin Cholesterol HDL Lipid metabolism Lipid Metabolism medicine.disease Lipids Endocrinology chemistry Insulin dependent diabetes Female lipids (amino acids peptides and proteins) Beta cell Diabetic patient Lipoproteins HDL business |
| Zdroj: | Diabetes Care. 6:351-355 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | The artificial beta-cell can establish normoglycemia within 2 h in an indifferently controlled diabetic patient. In the present study, the temporal relationship between the achievement of normoglycemia and its effect on plasma lipid concentrations has been examined in 12 insulin-dependent diabetic patients regulated by the artificial beta-cell for 7 days. The fasting values (mean +/- SEM) of blood glucose (BG), triglycerides (TG), total cholesterol (T-chol), HDL-cholesterol (HDL), and the calculated LDL/HDL ratio (obtained while participants were on single or split insulin regimens) were 385 +/- 42 mg/dl, 148 +/- 24 mg/dl, 219 +/- 22 mg/dl, 39 +/- 3.6 mg/dl, and 3.8 +/- 1.04, respectively. Within 12 h of establishing normoglycemia TG levels fell to 87 +/- 10 mg/dl (P less than 0.001), T-chol to 196 +/- 15 mg/dl (P less than 0.005), and HDL to 37 +/- 3 mg/dl (P = NS). The LDL/HDL ratio remained unchanged. After 7 days on the artificial beta-cell, the corresponding values were: 73 +/- 5 mg/dl (P less than 0.001), 169 +/- 9 mg/dl (P less than 0.001), 41 +/- 2.6 mg/dl (P = NS), and 2.6 +/- 0.56 (P less than 0.05). Twenty-four hours after discontinuation of artificial beta-cell therapy, the TG and T-chol concentrations reverted to baseline. These findings underscore the rapidity and effectiveness with which strict control can improve plasma lipid profiles. |
| Databáze: | OpenAIRE |
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