Porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV): A threat for xenotransplantation?
| Autor: | Mueller, Nicolas J, Denner, Joachim |
|---|---|
| Přispěvatelé: | University of Zurich, Denner, Joachim |
| Rok vydání: | 2022 |
| Předmět: |
Primates
2403 Immunology Transplantation porcine cytomegalovirus Swine PCR methods 2747 Transplantation Transplantation Heterologous Immunology Cytomegalovirus 610 Medicine & health Tissue Donors 10234 Clinic for Infectious Diseases herpes viruses Western blot analysis xenotransplantation Cytomegalovirus Infections Animals Humans porcine roseolovirus Roseolovirus 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit |
| DOI: | 10.5167/uzh-225153 |
| Popis: | The potential for a donor-derived transmission of porcine cytomegalovirus/porcine roseolovirus (PCMV/PRV) to the recipient has been recognized since pigs were considered candidate donors for xenotransplantation. This review gives a short description of the viral properties and summarizes the current evidence of the effects of PCMV/PRV transmission in preclinical xenotransplantation. Despite evidence that PCMV/PRV does not infect human and non-human primate cells, activation in the transplanted organ and detrimental systemic complications have been described. As PCMV/PRV is a herpesvirus able to establish latency, the importance of adequate screening of donor pigs is emphasized, as no efficient treatment is available. Furthermore, easy and successful ways of elimination of PCMV/PRV from pig herds are indicated. |
| Databáze: | OpenAIRE |
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