Cytokine-based transformation of immune surveillance into tumor-promoting inflammation
| Autor: | M Oft, John B. Mumm |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Cancer Research
medicine.medical_treatment Inflammation Biology medicine.disease_cause Interleukin-23 Models Biological Immune system Antigen Transforming Growth Factor beta Neoplasms Genetics Interleukin 23 medicine Animals Humans Immunologic Surveillance Molecular Biology Cell Proliferation Interleukin-6 Tumor Necrosis Factor-alpha Interleukin-12 Cytokine Tumor progression Immunology Cytokines Tumor necrosis factor alpha medicine.symptom Carcinogenesis |
| Zdroj: | Oncogene. 27:5913-5919 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/onc.2008.275 |
| Popis: | During the last decade, it has become clear that the mammalian immune system is able to recognize and partially suppress nascent tumors. Human T cells specific to oncogenes and onco-fetal antigens are present in human cancer patients and their tumors. At the same time, molecular links between tumor-associated inflammation and tumor progression have been uncovered, providing an explanation for the long recognized epidemiological link between inflammation and cancer. The synopsis of these findings suggests a new interpretation of tumor immunity. It appears that antigen recognition or antigen-specific T-cell expansion at large is not as profoundly impaired in tumor patients as the correct polarization, the survival and the effector function of tumor-infiltrating T cells. This review will focus on pro-inflammatory cytokines likely to contribute to the deregulation of tumor-specific immunity and its consequences. |
| Databáze: | OpenAIRE |
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