Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases
| Autor: | Didier Vieau, Fabien Delahaye, Francine Hughes, Arnaud Carrier, Jessica Tozour |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine lcsh:QR1-502 030209 endocrinology & metabolism Context (language use) Review Early memory medicine.disease_cause Bioinformatics Biochemistry programming lcsh:Microbiology Epigenesis Genetic 03 medical and health sciences prenatal hyperglycemia 0302 clinical medicine Metabolic Diseases Pregnancy Diabetes mellitus medicine Humans oxidative stress Obesity Epigenetics Risk factor Molecular Biology Glycemic Sex Characteristics business.industry medicine.disease metabolic disease Gestational diabetes Diabetes Gestational Glucose 030104 developmental biology Hyperglycemia Female Sugars business Oxidative stress |
| Zdroj: | Biomolecules, Vol 10, Iss 1359, p 1359 (2020) Biomolecules |
| Popis: | Worldwide, the number of people with diabetes has quadrupled since 1980 reaching 422 million in 2014 (World Health Organization). This distressing rise in diabetes also affects pregnant women and thus, in regard to early programming of adult diseases, creates a vicious cycle of metabolic dysfunction passed from one generation to another. Metabolic diseases are complex and caused by the interplay between genetic and environmental factors. High-glucose exposure during in utero development, as observed with gestational diabetes mellitus (GDM), is an established risk factor for metabolic diseases. Despite intense efforts to better understand this phenomenon of early memory little is known about the molecular mechanisms associating early exposure to long-term diseases risk. However, evidence promotes glucose associated oxidative stress as one of the molecular mechanisms able to influence susceptibility to metabolic diseases. Thus, we decided here to further explore the relationship between early glucose exposure and cellular stress in the context of early development, and focus on the concept of glycemic memory, its consequences, and sexual dimorphic and epigenetic aspects. |
| Databáze: | OpenAIRE |
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