Colchicine induces enhanced intestinal permeability in the rat
| Autor: | D. Zemer, A. Fradkin, A. Jonas, J. Yahav, A. Diver‐Haber |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Time Factors Physiology Urinary system Drinking Biology Excretion Lactulose chemistry.chemical_compound Internal medicine medicine Colchicine Animals Mannitol Rats Wistar Intestinal permeability Tight junction medicine.disease Epithelium Rats Intestines medicine.anatomical_structure Endocrinology chemistry Intestinal Absorption medicine.drug |
| Zdroj: | Acta physiologica Scandinavica. 153(3) |
| ISSN: | 0001-6772 |
| Popis: | Intestinal permeability was determined in rats receiving colchicine 0.5 +/- 0.15 mg day-1 in drinking water (30 mg L-1) for periods up to 23 days. The lactulose/mannitol method was used to determine whole gut permeability before and on days 2, 4, 8, 18 and 23 of colchicine administration. The 8-h urinary lactulose excretion following the test meal increased significantly in rats receiving colchicine, compared with the pretreatment value. Increased lactulose permeability was present after 2 days and remained stable throughout the experimental period. Mannitol urinary excretion was not changed. Colchicine increases intestinal tight junction permeability by an as yet undetermined mechanism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text