Human immunodeficiency virus-related primary central nervous system lymphoma: factors influencing survival in 111 patients
| Autor: | Bruce J. Brew, Andrew E. Grulich, Bernadette DeGraaff, Stephen Cooper, M. Newell, Jennifer F Hoy, Jeremy Millar, David I. Quinn, Melissa Bryant |
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| Rok vydání: | 2004 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty medicine.medical_treatment Central Nervous System Neoplasms Internal medicine Antiretroviral Therapy Highly Active medicine Humans Survival rate Lymphoma AIDS-Related Retrospective Studies Chemotherapy business.industry Incidence (epidemiology) Incidence Primary central nervous system lymphoma Cancer Retrospective cohort study Middle Aged medicine.disease Prognosis Radiation therapy Survival Rate Immunology Adjunctive treatment Female business |
| Zdroj: | Cancer. 100(12) |
| ISSN: | 0008-543X |
| Popis: | BACKGROUND The current study evaluated factors influencing survival in patients diagnosed with human immunodeficiency virus (HIV)-related primary central nervous system lymphoma (PCNSL), with a focus on the effects of therapeutic radiotherapy (RT) and highly active antiretroviral therapy (HAART). METHODS A retrospective chart review of patients with a diagnosis of HIV-related PCNSL at one of five university hospitals between 1987 and 1998 was performed. Clinical details including antiretroviral agent use, brain imaging scan results, RT use, and survival outcomes were recorded. RESULTS One hundred eleven patients with HIV-related PCNSL were identified. The annual incidence decreased significantly between 1992 and 1995 and between 1996 and 1998 (P = 0.04). The median survival period was 50 days (mean, 109 days; range, 4–991 days), with improved survival for patients diagnosed after 1993. Patients treated with two or more antiretroviral agents had improved survival (P = 0.01), as did patients who received RT (P < 0.0001). For patients who received RT, completion of the prescribed course and treatment to ≥ 30 Gray (Gy) independently predicted a more favorable outcome. RT used in conjunction with antiretroviral therapy involving two or more agents had an additive positive effect on survival. For patients who did not receive RT, poor performance status and encephalopathy predicted a shorter survival duration. CONCLUSIONS The results of the current study suggest that HAART and treatment with RT to ≥ 30 Gy improve survival for patients with HIV-related PCNSL. This combination of therapies may provide a standard of care as the basis for further trials of chemotherapy, novel adjunctive treatment, and quality of life assessment. Cancer 2004. © 2004 American Cancer Society. |
| Databáze: | OpenAIRE |
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