Chemotherapy for the Management of Cerebral Metastases
| Autor: | Jonathan H. Sherman, Pooja Dave, Chase H. Foster |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Focused ultrasound Cerebral metastasis 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Drug Therapy Internal medicine medicine Adjuvant therapy Humans Chemotherapy Neovascularization Pathologic business.industry Brain Neoplasms Retrospective cohort study General Medicine Clinical trial Treatment Outcome 030220 oncology & carcinogenesis Surgery Neurology (clinical) Neurosurgery business 030217 neurology & neurosurgery |
| Zdroj: | Neurosurgery clinics of North America. 31(4) |
| ISSN: | 1558-1349 |
| Popis: | Chemotherapy has played a minor role as adjuvant therapy in treatment of cerebral metastases from solid cancers. The blood-brain barrier and cerebral metastases' considerable machinery of self-preservation have been significant obstacles to delivery and efficacy of chemotherapy. However, several methods intended to surmount these challenges have arisen alongside advent of technology and with the development of targeted molecular therapies. Focused ultrasound and molecular Trojan horses represent two such novel means of increasing permeability of the blood-brain barrier to effector agents. Published data on efficacy of these targeted therapies remain mostly restricted to retrospective studies and phase II prospective clinical trials. |
| Databáze: | OpenAIRE |
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