p53: A Key Protein That Regulates Pulmonary Fibrosis
| Autor: | Qi Wu, Yue Shi, Ke-jia Zhang, Ru-Bin Tan, Yao Zhou, Jie Cui, Shi-min Jiang, Lu Fu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Aging
Tumor suppressor gene Pulmonary Fibrosis Disease Review Article medicine.disease_cause Bioinformatics Biochemistry Malignant transformation Pathogenesis Pulmonary fibrosis medicine Animals Humans QH573-671 business.industry Neoplastic disease Cell Biology General Medicine medicine.disease Prognosis Clinical diagnosis Tumor Suppressor Protein p53 business Carcinogenesis Cytology |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2020 (2020) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern. Although the incidence of this disease is increasing, there is a lack of effective therapies. In recent years, the pathogenesis of pulmonary fibrosis has become a research hotspot. p53 is a tumor suppressor gene with crucial roles in cell cycle, apoptosis, tumorigenesis, and malignant transformation. Previous studies on p53 have predominantly focused on its role in neoplastic disease. Following in-depth investigation, several studies have linked it to pulmonary fibrosis. This review covers the association between p53 and pulmonary fibrosis, with the aim of providing novel ideas to improve the clinical diagnosis, treatment, and prognosis of pulmonary fibrosis. |
| Databáze: | OpenAIRE |
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