Proper macrophagic differentiation requires both autophagy and caspase activation
| Autor: | Sandrine Obba, Eric Solary, Patrick Auberger, Arnaud Jacquel |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Macrophage colony-stimulating factor
Programmed cell death Phagocytosis Cellular differentiation Protein Serine-Threonine Kinases Autophagy-Related Protein 7 Monocytes Cathepsin B Mice Autophagy Autophagy-Related Protein-1 Homolog Animals Humans Macrophage RNA Small Interfering Molecular Biology Cells Cultured Caspase Mice Knockout biology Macrophage Colony-Stimulating Factor Macrophages Cell Differentiation Cell Biology Autophagic Punctum Cell biology Gene Expression Regulation Monocyte differentiation biology.protein Microtubule-Associated Proteins |
| Zdroj: | Autophagy. 8:1141-1143 |
| ISSN: | 1554-8635 1554-8627 |
| DOI: | 10.4161/auto.20367 |
| Popis: | Autophagy allows the elimination of superfluous or damaged macromolecules or organelles. Genetic evidence indicates that autophagy plays essential functions during differentiation. The differentiation of human blood monocytes into macrophages is a caspase-dependent process triggered by colony stimulating factor1 (CSF1/CSF-1). We have established, using pharmacological inhibitors, siRNA approaches and Atg7 (-/-) mice, that autophagy is required for proper CSF1/CSF-1-driven differentiation of human and murine monocytes and acquisition of phagocytic functions. Collectively, these findings highlight an essential role of autophagy during monocyte differentiation and acquisition of macrophage functions. Deciphering the complex interplay between caspase and autophagy that occurs during this process will undoubtedly bring new insights in our understanding of monocyte differentiation. |
| Databáze: | OpenAIRE |
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