Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome
| Autor: | Fadime Aydin-Kose, Yakut Akyön, Cem Karagözlü, Banu Pınar Sarer-Yurekli, Ezgi Bellikci-Koyu, Koray Ergünay, Annika Brinkmann, Andreas Nitsche, Ahmet Gokhan Ozgen, Engin Yilmaz, Zehra Buyuktuncer |
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| Přispěvatelé: | Ege Üniversitesi, Beslenme ve Diyetetik, Acibadem University Dspace |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Blood Glucose Male 0301 basic medicine Adolescent medicine.medical_treatment Physiology lcsh:TX341-641 Gut flora kefir Article metabolic syndrome law.invention Young Adult 03 medical and health sciences Randomized controlled trial law medicine Humans ddc:610 Phylogeny Feces Aged 030109 nutrition & dietetics Nutrition and Dietetics biology gut microbiota Insulin ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS Body Weight Verrucomicrobia Bacteroidetes Middle Aged biology.organism_classification medicine.disease Lipids Gastrointestinal Microbiome ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ComputingMethodologies_PATTERNRECOGNITION 030104 developmental biology Blood pressure Female InformationSystems_MISCELLANEOUS Metabolic syndrome 610 Medizin und Gesundheit lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Volume 11 Issue 9 Nutrients, Vol 11, Iss 9, p 2089 (2019) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11092089 |
| Popis: | YILMAZ, Engin/0000-0001-8873-7645; Ergunay, Koray/0000-0001-5422-1982; Karagozlu, Cem/0000-0002-2874-4998; Kose, Fadime Aydin/0000-0001-5222-7555; bellikci koyu, ezgi/0000-0001-5279-2394 WOS: 000487964600296 PubMed: 31487797 Several health-promoting effects of kefir have been suggested, however, there is limited evidence for its potential effect on gut microbiota in metabolic syndrome This study aimed to investigate the effects of regular kefir consumption on gut microbiota composition, and their relation with the components of metabolic syndrome. in a parallel-group, randomized, controlled clinical trial setting, patients with metabolic syndrome were randomized to receive 180 mL/day kefir (n = 12) or unfermented milk (n = 10) for 12 weeks. Anthropometrical measurements, blood samples, blood pressure measurements, and fecal samples were taken at the beginning and end of the study. Fasting insulin, HOMA-IR, TNF-alpha, IFN-gamma, and systolic and diastolic blood pressure showed a significant decrease by the intervention of kefir (p 0.05 for each). Gut microbiota analysis showed that regular kefir consumption resulted in a significant increase only in the relative abundance of Actinobacteria (p = 0.023). No significant change in the relative abundance of Bacteroidetes, Proteobacteria or Verrucomicrobia by kefir consumption was obtained. Furthermore, the changes in the relative abundance of sub-phylum bacterial populations did not differ significantly between the groups (p > 0.05, for each). Kefir supplementation had favorable effects on some of the metabolic syndrome parameters, however, further investigation is needed to understand its effect on gut microbiota composition. Turkish Council of Higher EducationMinistry of National Education - Turkey This research was funded by the Turkish Council of Higher Education. |
| Databáze: | OpenAIRE |
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