Alzheimer’s Disease Progressively Reduces Visual Functional Network Connectivity
| Autor: | David C. Zhu, Jie Huang, Paul A. Beach, Andrea Bozoki |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Research Report
0301 basic medicine Postmortem studies genetic structures media_common.quotation_subject Disease Functional networks 03 medical and health sciences 0302 clinical medicine medicine Contrast (vision) resting-state visual functional connectivity network Association (psychology) media_common Fusiform gyrus business.industry FAUPA functional areas of unitary pooled activity General Neuroscience Psychiatry and Mental health Clinical Psychology 030104 developmental biology Visual cortex medicine.anatomical_structure Biomarker (medicine) face-evoked visual-processing network Geriatrics and Gerontology business Alzheimer’s disease Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease Reports |
| ISSN: | 2542-4823 |
| DOI: | 10.3233/adr-210017 |
| Popis: | Background: Postmortem studies of brains with Alzheimer’s disease (AD) not only find amyloid-beta (Aβ) and neurofibrillary tangles (NFT) in the visual cortex, but also reveal temporally sequential changes in AD pathology from higher-order association areas to lower-order areas and then primary visual area (V1) with disease progression. Objective: This study investigated the effect of AD severity on visual functional network. Methods: Eight severe AD (SAD) patients, 11 mild/moderate AD (MAD), and 26 healthy senior (HS) controls undertook a resting-state fMRI (rs-fMRI) and a task fMRI of viewing face photos. A resting-state visual functional connectivity (FC) network and a face-evoked visual-processing network were identified for each group. Results: For the HS, the identified group-mean face-evoked visual-processing network in the ventral pathway started from V1 and ended within the fusiform gyrus. In contrast, the resting-state visual FC network was mainly confined within the visual cortex. AD disrupted these two functional networks in a similar severity dependent manner: the more severe the cognitive impairment, the greater reduction in network connectivity. For the face-evoked visual-processing network, MAD disrupted and reduced activation mainly in the higher-order visual association areas, with SAD further disrupting and reducing activation in the lower-order areas. Conclusion: These findings provide a functional corollary to the canonical view of the temporally sequential advancement of AD pathology through visual cortical areas. The association of the disruption of functional networks, especially the face-evoked visual-processing network, with AD severity suggests a potential predictor or biomarker of AD progression. |
| Databáze: | OpenAIRE |
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