Synthesis of 2-(N,N-Dialkylaminomethyl)-7-phenylthioindoles

Autor:	John Andrako, Robert L. Duncan
Rok vydání:	1968
Předmět:	Indoles Magnetic Resonance Spectroscopy ALUMINUM HYDRIDE Pharmaceutical Science chemistry.chemical_element Lithium Medicinal chemistry Nmr data chemistry Phenothiazines Spectrophotometry Organic chemistry Indicators and Reagents Phosphoric Acids Aluminum
Zdroj:	Journal of Pharmaceutical Sciences. 57:979-983
ISSN:	0022-3549
DOI:	10.1002/jps.2600570612
Popis:	A series of 2-( N,N -dialkylaminomethyl)-7-phenylthioindoles was prepared. The Japp-Klingemann reaction followed by Fisher cyclization with polyphosphoric acid gave 7-phenylthioindole-2-carboxylic acid. The lithium aluminum hydride reduction of amides derived from this acid provided the corresponding aminomethyl indoles. Infrared and NMR data are reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8403e1a0b8831b5947a75267ff3d2a1 https://doi.org/10.1002/jps.2600570612 Zobrazit plný text záznamu Plný text