Placental 11β-hydroxysteroid dehydrogenase activity in normotensive and pre-eclamptic pregnancies
| Autor: | Vijaya L. Nacharaju, Cyrus O. McCalla, Ozgul Muneyyirci-Delale, Joseph Feldman, Sandra Glasgow |
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| Rok vydání: | 1998 |
| Předmět: |
endocrine system
medicine.medical_specialty Placenta Pregnancy Trimester Third Clinical Biochemistry Biochemistry Umbilical cord Preeclampsia Endocrinology Pre-Eclampsia Pregnancy Fetal membrane Internal medicine medicine Humans Molecular Biology Hydrocortisone Pharmacology business.industry Organic Chemistry Hydroxysteroid Dehydrogenases Gestational age NAD medicine.disease medicine.anatomical_structure 11-beta-Hydroxysteroid Dehydrogenases Female Cortisone business NADP medicine.drug |
| Zdroj: | Steroids. 63:511-515 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/s0039-128x(98)00056-7 |
| Popis: | Apparent mineralocorticoid excess and licorice induced hypertension, both hypertensive disorders, have been attributed to a defect in the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), which interconverts cortisol to cortisone. Therefore, we undertook this study to determine the role of human placental 11 beta-HSD activity in preeclampsia, which is a hypertensive disorder in pregnancy. 11 beta-HSD activities were determined in placentas of 17 normotensive and 11 preeclamptic patients matched for gestational age at 34-42 weeks. Cortisol levels in umbilical venous and arterial sera were also determined for both groups. Statistical analysis was performed using Student's t-test, significance at p < 0.05. 11 beta-dehydrogenase (oxidation activity of 11 beta-HSD) activity was significantly lower in placentas of preeclamptic compared to normotensive patients (0.19 +/- 0.09 vs. 0.26 +/- 0.08 mmoles/min/placenta, p = 0.02). Cortisol level in umbilical cord blood was significantly higher in the preeclamptic group (14.99 +/- 14.08 vs. 6.71 +/- 3.69 g/dL, p = 0.02). The decreased 11 beta-HSD activity is accompanied by an expected increase in umbilical cord blood cortisol level and decrease in fetal weight. This enzyme may play an important role in influencing fetal growth. |
| Databáze: | OpenAIRE |
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