High Seroprevalence of CMV Among Women of Childbearing Age Implicates High Burden of Congenital Cytomegalovirus Infection in Poland
| Autor: | Milena Dunal-Szcepaniak, Agnieszka Trzcińska, Paulina Godzik, Joanna Siennicka, Magdalena Rosińska |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Pediatrics medicine.medical_specialty lcsh:QH426-470 Adolescent Secondary infection 030106 microbiology lcsh:QR1-502 High seroprevalence Age dependent Applied Microbiology and Biotechnology Microbiology lcsh:Microbiology 03 medical and health sciences Young Adult 0302 clinical medicine congenital CMV sequelae Pregnancy Seroepidemiologic Studies medicine Humans 030212 general & internal medicine Young adult business.industry Incidence (epidemiology) CMV IgG prevalence Infant Newborn General Medicine Middle Aged medicine.disease CMV in Poland Infectious Disease Transmission Vertical lcsh:Genetics women of childbearing age Immunology Childbearing age congenital CMV infection Cytomegalovirus Infections Female Poland business Live birth |
| Zdroj: | Polish Journal of Microbiology, Vol 65, Iss 4 (2016) |
| ISSN: | 1733-1331 |
| Popis: | Cytomegaloviruses are common worldwide, with variable frequency of infections. The infection in pregnancy may lead to pregnancy loss or serious sequelae for the child. To understand the risk posed by CMV in Poland we conducted cross-sectional study on women aged 15–49 basing on existing serum bank. Age dependent CMV incidence, the rates of congenital infection and sequelae were modelled from sero-prevalence, literature and demographic data. The overall anti-CMV IgG prevalence was 81.9% increasing from 74.3% in < 30 years old to 94.3% in subjects 45+ years old. The lowest incidence was estimated at the age of 15 and the highest at the age 34 (3.8 and 8.95 respec- tively/100 women/year). The estimated rate of cCMV varies from 22.4 to 37.2 per 1000 live birth depending on the assumptions made. The proportion of cases due to secondary infection ranged from 34.8% to 49.9% accordingly. |
| Databáze: | OpenAIRE |
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