Favipiravir (SARS-CoV-2) degradation impurities: Identification and route of degradation mechanism in the finished solid dosage form using LC/LC-MS method
| Autor: | Divya Kumar Vemuri, Rambabu Gundla, Naresh Konduru, Ravindra Mallavarapu, Naresh Kumar Katari |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Pharmacology
Acetonitriles SARS-CoV-2 Clinical Biochemistry COVID-19 Reproducibility of Results General Medicine Biochemistry Amides Analytical Chemistry Drug Stability Tandem Mass Spectrometry Pyrazines Drug Discovery Humans Drug Contamination Molecular Biology Chromatography High Pressure Liquid Chromatography Liquid |
| Zdroj: | Biomedical chromatography : BMC. 36(6) |
| ISSN: | 1099-0801 |
| Popis: | Favipiravir finished dosage was approved for emergency use in many countries to treat SARS-CoV-2 patients. A specific, accurate, linear, robust, simple, and stability-indicating HPLC method was developed and validated for the determination of degradation impurities present in favipiravir film-coated tablets. The separation of all impurities was achieved from the stationary phase (Inert sustain AQ-C18, 250 × 4.6 mm, 5-μm particle) and mobile phase. Mobile phase A contained KH |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text