Susceptibilities of ESBL-Producing Enterobacteriaceae to Ertapenem, Meropenem and Piperacillin-Tazobactam with and without Clavulanic Acid
| Autor: | Ellen Broide, Bernard Rudensky, David Raveh, Amos M. Yinnon |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Ertapenem
Esbl production Penicillanic Acid Microbial Sensitivity Tests beta-Lactams Meropenem beta-Lactamases Microbiology chemistry.chemical_compound Clavulanic acid Drug Discovery Escherichia coli polycyclic compounds medicine Drug Interactions Pharmacology (medical) Beta-Lactamase Inhibitors Clavulanic Acid Piperacillin Pharmacology biology business.industry General Medicine biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Enterobacteriaceae Anti-Bacterial Agents body regions Klebsiella pneumoniae Piperacillin Tazobactam Drug Combination Infectious Diseases Oncology chemistry Piperacillin/tazobactam bacteria Thienamycins beta-Lactamase Inhibitors business medicine.drug |
| Zdroj: | Chemotherapy. 53:185-189 |
| ISSN: | 1421-9794 0009-3157 |
| Popis: | Background: Faced with the extended-spectrum β-lactamase (ESBL) pandemic, we compared the susceptibilities of ESBL-producing Enterobacteriaceae to ertapenem, meropenem and piperacillin-tazobactam with and without clavulanate. Methods: 121 strains of Escherichia coli and Klebsiella were studied. 70 strains were originally reported as resistant to ceftazidime based upon disk diffusion; 51 strains were originally reported as sensitive to ceftazidime based upon previous guidelines of the National Committee for Clinical Laboratory Standards, but subsequently shown to be ESBL producers. Minimal inhibitory concentrations (MICs) of the strains towards ertapenem, meropenem and piperacillin-tazobactam were determined by Etest. The effect of adding clavulanate on the MICs was determined by performing the Etest, using plates containing 2 µg/ml of clavulanate. Results: The MIC90 of all isolates was 0.094 and 0.25 µg/ml for ertapenem, 0.032 and 0.064 µg/ml for meropenem, and 16 and 256 µg/ml for piperacillin-tazobactam with and without clavulanate, respectively. Conclusions: ESBL-producing organisms were more susceptible to meropenem than to ertapenem, although the MICs to ertapenem were well within clinically achievable levels. Piperacillin-tazobactam was ineffective in a large percentage of isolates. The presence of clavulanate resulted in a 5-fold decrease in the MIC of ertapenem and in a drastic reduction in the MIC of piperacillin-tazobactam. The decrease observed with ertapenem is unlikely to be of clinical significance. Thus, in our hospital, ertapenem could be a good meropenem-sparing agent for infections due to ESBL-producing organisms. Piperacillin-tazobactam appeared to be a poor choice, as our isolates produce ESBLs which are not successfully inhibited by tazobactam. |
| Databáze: | OpenAIRE |
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