Allelic association but only weak evidence for linkage to the apolipoprotein E locus in late-onset Swedish Alzheimer families
| Autor: | Charlotte Forsell, Lena Lilius, Elizabeth H. Corder, Li Liu, Karin Axelman, Lars Lannfelt |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Apolipoprotein E Apolipoprotein E2 Genetic Linkage Apolipoprotein E4 Apolipoprotein E3 Locus (genetics) Gene mutation Biology Apolipoproteins E Gene mapping Alzheimer Disease Genetic linkage Chromosome 19 medicine Humans Age of Onset Allele Alleles Genetics (clinical) Aged Sweden Genetics Middle Aged medicine.disease Female Alzheimer's disease |
| Zdroj: | American Journal of Medical Genetics. 67:306-311 |
| ISSN: | 1096-8628 0148-7299 |
| Popis: | An association between the {epsilon}4 allele of the apolipoprotein E gene (APOE) and late-onset Alzheimer`s disease (AD) was recently demonstrated. In order to confirm the association and to gauge the ability of standard genetic linkage methods to identify susceptibility genes, we investigated 15 Swedish late-onset AD families. We found an association of familial AD to the APOE {epsilon}4 allele (P = 0.01) but no indication of linkage to the APOE region using 2-point linkage analysis, and only weak evidence using the affected pedigree-member (APM) method. Our results confirm an APOE {epsilon}4 association with late-onset familial AD and indicate that susceptibility genes can easily be missed when using standard lod score and APM genetic linkage analysis. 19 refs., 1 fig., 4 tabs. |
| Databáze: | OpenAIRE |
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