Gingival Recession and Localized Aggressive Periodontitis Among HIV-infected Children and Adolescents Receiving Antiretroviral Therapy
| Autor: | Piet J. Becker, Theresa M. Rossouw, Ute Dagmar Feucht, Elaine Blignaut, Diana S. Mavuso |
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| Rok vydání: | 2018 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Adolescent Cross-sectional study Anti-HIV Agents MEDLINE HIV Infections Treatment failure 03 medical and health sciences South Africa Young Adult 0302 clinical medicine 030225 pediatrics Hiv infected Internal medicine Antiretroviral Therapy Highly Active Prevalence Medicine Aggressive periodontitis Humans Gingival Recession 030212 general & internal medicine Treatment Failure Young adult Child Gingival recession business.industry Viral Load medicine.disease Antiretroviral therapy CD4 Lymphocyte Count Infectious Diseases Cross-Sectional Studies Aggressive Periodontitis Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom business |
| Zdroj: | The Pediatric infectious disease journal. 38(6) |
| ISSN: | 1532-0987 |
| Popis: | Limited information is available on gingival recession or localized aggressive periodontitis among HIV-infected children and adolescents. This study reports on the prevalence of these conditions among children and adolescents receiving antiretroviral therapy (ART).A cross-sectional study on HIV-infected children and adolescents attending a Pediatric HIV clinic in Gauteng, South Africa, between January 2013 and June 2016. Patients received an oral examination and oral hygiene instructions, irrespective of oral- or dental-related complaints. Hard and soft tissue pathology was managed and recorded, together with relevant demographic and clinical data. Statistical analysis was performed in Stata 14 with P0.05 as significant.A total of 554 children and adolescents 5-19 years of age (median age: 12.2 years; interquartile range: 10.3-14.9) were included, of whom 78 (14.1%) presented with gingival recession on permanent mandibular incisors and/or localized aggressive periodontitis of molar teeth. Multivariable logistic regression revealed that patients with gingival recession and aggressive periodontitis had a significantly shorter duration of ART and were more likely to have suboptimal HIV control (CD4 count ≤500 cells/µL and/or HIV viral load ≥50 copies/mL) and be on advanced ART regimens after virologic failure on first- and second-line treatment.The results emphasize the importance of oral health care among HIV-infected children and adolescents from the onset, to prevent and manage conditions that could result in tooth loss and permanent disfigurement. This is of particular importance in the presence of virologic failure and immunosuppression. |
| Databáze: | OpenAIRE |
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