Mechnetor: a web server for exploring protein mechanism and the functional context of genetic variants
| Autor: | Ivo C Leist, Robert B. Russell, Kyle R Weise, Mustafa F R Ibrahim, Juan Carlos González-Sánchez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Web server
AcademicSubjects/SCI00010 Protein domain Genomics Context (language use) Computational biology Biology Proteomics computer.software_genre Protein–protein interaction 03 medical and health sciences Mice 0302 clinical medicine Interaction network Neoplasms Protein Interaction Mapping Genetics Animals Humans Protein Interaction Domains and Motifs 030304 developmental biology 0303 health sciences Internet Genetic Diseases Inborn Genetic Variation Proteins Protein tertiary structure Web Server Issue computer Protein Processing Post-Translational 030217 neurology & neurosurgery Software |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | Advances in DNA sequencing and proteomics mean that researchers must now regularly interrogate thousands of positional gene/protein changes in order to find those relevant for potential clinical application or biological insights. The abundance of already known information on protein interactions, mechanism, and tertiary structure provides the possible means to understand these changes rapidly, though a careful and systematic integration of these diverse datasets is first needed. For this purpose, we developed Mechnetor, a tool that allows users to quickly explore and visualize integrated mechanistic data for proteins or interactions of interest. Central to the system is a careful cataloguing of diverse sources of protein interaction mechanism, and an efficient means to visualize interactions between relevant and/or known protein regions. The result is a finer resolution interaction network that provides more immediate clues as to points of intervention or mechanistic understanding. Users can import protein, interactions, genetic variants or post-translational modifications and see these data in the best known mechanistic context. We demonstrate the tool with topical examples in human genetic diseases and cancer genomics. The tool is freely available at: mechnetor.russelllab.org. Graphical Abstract Graphical AbstractOverview of Mechnetor showing examples of interaction mechanisms overlayed with disease variants. |
| Databáze: | OpenAIRE |
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