Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention

Autor: Zi‐jian Guo, Chunwei Li, Guo‐xun Li, Dong‐jing Li, Kang Yu, Song‐lin Yu, Rong‐ji Liu, Hai‐yan Xie, Ng Shyh-Chang, Kang Li, Jie Ying, Long‐yu Xu, Ling‐juan Jiang, Rong-rong Li
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Aging
Sarcopenia
lcsh:Diseases of the musculoskeletal system
medicine.medical_treatment
Severity of Illness Index
0302 clinical medicine
Elderly
Orthopedics and Sports Medicine
Longitudinal Studies
Prospective Studies
Lifestyle interventions
Confounding
Cytokine TWEAK
lcsh:Human anatomy
Middle Aged
Treatment Outcome
030220 oncology & carcinogenesis
Cohort
Body Composition
Original Article
Female
Inflammation Mediators
China
medicine.medical_specialty
Proinflammatory cytokine
lcsh:QM1-695
03 medical and health sciences
Physiology (medical)
Internal medicine
medicine
Humans
Healthy Lifestyle
Muscle
Skeletal
Aged
Inflammation
Proinflammatory cytokines
Adiponectin
Tumor Necrosis Factor-alpha
business.industry
Insulin
Resistance Training
Original Articles
medicine.disease
Regimen
Cross-Sectional Studies
030104 developmental biology
Metabolic hormones
lcsh:RC925-935
business
Hormone
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 3, Pp 586-600 (2019)
Journal of Cachexia, Sarcopenia and Muscle
ISSN: 2190-5991
2190-6009
Popis: Background Ageing, chronic diseases, prolonged inactivity, and inadequate nutrition pose a severe threat to skeletal muscle health and function. To date, experimental evidence suggests that ageing‐related subclinical inflammation could be an important causative factor in sarcopenia. Although inflammatory signalling has been implicated in the pathogenesis of experimental animal models of sarcopenia, few studies have surveyed the clinical association between circulating factors and muscle mass in patients before and after lifestyle interventions. In this study, we evaluated whether proinflammatory cytokines are associated with the onset of sarcopenia, which circulating factors are associated with the severity of sarcopenia, and how these factors change after lifestyle interventions in sarcopenic elderly persons. Methods A total of 56 elderly subjects (age ≥ 60 years) with sarcopenia and 56 elderly non‐sarcopenic subjects, who met entry criteria and had given informed consent, were selected from the Peking Union Medical College Hospital multicentre prospective longitudinal sarcopenia study for testing relevant circulating factors. Thirty‐two elderly subjects from the sarcopenic cohort completed a 12 week intensive lifestyle intervention programme with whey supplements (30 g/day) and a personalized resistance training regimen. The levels of proinflammatory cytokines and metabolic hormones, pre‐intensive and post‐intensive lifestyle interventions, were measured. Results The sarcopenic group was significantly older (72.05 ± 6.54 years; P 11.15 pg/mL) and TWEAK (>1276.48 pg/mL) were associated with a 7.6‐fold and 14.3‐fold increased risk of sarcopenia, respectively. After adjustment for confounding variables, high levels of TWEAK were still associated with a 13.4‐fold increased risk of sarcopenia. Intensive lifestyle interventions led to significant improvements in sarcopenic patients' muscle mass and serum profiles of TWEAK, TNF‐α, IL‐18, insulin, and adiponectin (all P
Databáze: OpenAIRE
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