Metronidazole release using natural rubber latex as matrix
| Autor: | Osvaldo Novais de Oliveira Junior, Rondinelli Donizetti Herculano, Marco Antonio Hungaro Duarte, Gustavo Campos Belmonte, Carlos Frederico de Oliveira Graeff, Angela Kinoshita, Sérgio Augusto Catanzaro Guimarães |
|---|---|
| Přispěvatelé: | Universidade de São Paulo (USP), Universidade do Sagrado Coração, Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2010 |
| Předmět: |
Inert
Chromatography Ethanol Materials science Nitroimidazole Mechanical Engineering POLÍMEROS (MATERIAIS) latex membrane Condensed Matter Physics In vitro Matrix (chemical analysis) chemistry.chemical_compound metronidazole Membrane chemistry Polymerization Mechanics of Materials lcsh:TA401-492 drug delivery system Organic chemistry lcsh:Materials of engineering and construction. Mechanics of materials General Materials Science Anaerobic bacteria biomaterials |
| Zdroj: | SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Materials Research, Volume: 13, Issue: 1, Pages: 57-61, Published: MAR 2010 Materials Research v.13 n.1 2010 Materials research (São Carlos. Online) Universidade Federal de São Carlos (UFSCAR) instacron:ABM ABC ABPOL Materials Research, Vol 13, Iss 1, Pp 57-61 (2010) |
| ISSN: | 1516-1439 |
| DOI: | 10.1590/s1516-14392010000100013 |
| Popis: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:05:38Z No. of bitstreams: 1 S1516-14392010000100013.pdf: 1491365 bytes, checksum: b2baad51426ce684b6bc236acd32b647 (MD5) Made available in DSpace on 2013-08-22T19:05:38Z (GMT). No. of bitstreams: 1 S1516-14392010000100013.pdf: 1491365 bytes, checksum: b2baad51426ce684b6bc236acd32b647 (MD5) Previous issue date: 2010-03-01 Made available in DSpace on 2013-09-30T20:09:34Z (GMT). No. of bitstreams: 2 S1516-14392010000100013.pdf: 1491365 bytes, checksum: b2baad51426ce684b6bc236acd32b647 (MD5) S1516-14392010000100013.pdf.txt: 22455 bytes, checksum: 979b8025d053489833d3e34bb7e04a65 (MD5) Previous issue date: 2010-03-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:26:11Z No. of bitstreams: 2 S1516-14392010000100013.pdf: 1491365 bytes, checksum: b2baad51426ce684b6bc236acd32b647 (MD5) S1516-14392010000100013.pdf.txt: 22455 bytes, checksum: 979b8025d053489833d3e34bb7e04a65 (MD5) Made available in DSpace on 2014-05-20T13:26:11Z (GMT). No. of bitstreams: 2 S1516-14392010000100013.pdf: 1491365 bytes, checksum: b2baad51426ce684b6bc236acd32b647 (MD5) S1516-14392010000100013.pdf.txt: 22455 bytes, checksum: 979b8025d053489833d3e34bb7e04a65 (MD5) Previous issue date: 2010-03-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Natural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed. MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the membrane polymerized at -100 °C, which does release 77,1% of its MET content for up 310 hours. USP Instituto de Física de São Carlos Departamento de Física e Ciências dos Materiais Universidade do Sagrado Coração UNESP Faculdade de Ciências Departamento de Física UNESP Faculdade de Ciências Departamento de Física |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|