Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice
| Autor: | Yong Joon Jeong, Se Chan Kang, Rina So, Jeong Eun Kwon, Young Geun Lee, Dae Won Park, Tae Hwan Choe, Hyelin Jeon |
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| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis 010501 environmental sciences Pharmacology Toxicology medicine.disease_cause 030226 pharmacology & pharmacy 01 natural sciences BALB/c Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lactate dehydrogenase medicine 0105 earth and related environmental sciences Liver injury Centella biology business.industry digestive oral and skin physiology biology.organism_classification Malondialdehyde medicine.disease Acetaminophen chemistry Original Article business Oxidative stress medicine.drug |
| Zdroj: | Toxicol Res |
| ISSN: | 2234-2753 1976-8257 |
| DOI: | 10.1007/s43188-020-00063-0 |
| Popis: | N-acetyl-p-aminophenol (acetaminophen, APAP) is a well-known component of analgesic and antipyretic monotherapy products. However, exceeding the recommended dose can lead to serious injury to the liver. We conducted this study to determine the potential of Centella asiatica as a natural substance to protect against APAP-induced liver injury. When acute hepatotoxicity was induced in mice by APAP overdose, their liver weight decreased significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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