Hydrophobic ion-pairing assembled liposomal Rhein with efficient loading for acute pancreatitis treatment
| Autor: | Jinjie Zhang, Yaru Xu, Jianbo Li, Shuaishuai Wang, Tiange Feng, Zhilei Liu, Huijie Cai |
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| Rok vydání: | 2021 |
| Předmět: |
Biodistribution
Liposome Chromatography Chemistry Organic Chemistry Rat model Pharmaceutical Science Bioengineering Anthraquinones medicine.disease Systemic circulation Rats Colloid and Surface Chemistry Hydrophobic ion Pancreatitis Acute Disease Liposomes Spectroscopy Fourier Transform Infrared medicine Acute pancreatitis Animals Tissue Distribution Particle size Physical and Theoretical Chemistry |
| Zdroj: | Journal of microencapsulation. 38(7-8) |
| ISSN: | 1464-5246 |
| Popis: | AIM The present study aimed to develop liposomal Rhein by employing a hydrophobic ion-pairing technique (HIP) for improved pancreatitis therapy. METHODS F127 modified liposomal Rhein (F127-RPC-Lip) was prepared using a two-step process consisting of complexation first, followed by a film-ultrasonic dispersion step. The drug-phospholipid interaction was characterised by FT-IR and P-XRD. Particle size and morphology were investigated using DLS and TEM, respectively. Biodistribution and therapeutic efficacy of F127-RPC-Lip were evaluated in a rat model of acute pancreatitis. RESULTS F127-RPC-Lip achieved efficient drug encapsulation after complexation with lipids through non-covalent interactions and had an average hydrodynamic diameter of about 141 nm. F127-RPC-Lip demonstrated slower drug release (55.90 ± 3.60%, w/w) than Rhein solution (90.27 ± 5.11%) within 24 h. Compared with Rhein, F127-RPC-Lip exhibited prolonged systemic circulation time, superior drug distribution, and attenuated injury in the pancreas of rats post-injection. CONCLUSIONS HIP-assembled liposomes are a promising strategy for Rhein in treating pancreatitis. |
| Databáze: | OpenAIRE |
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