Tumour-Associated Trypsin Inhibitor and Renal Cell Carcinoma
| Autor: | S. Bassi, M.-H. Schlageter, A. Le Duc, Paul Meria, François Desgrandchamps, T. Janssen, Ariane Cortesse, Toubert Me, Pierre Teillac, Olivier Cussenot |
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| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Pathology Urology medicine.medical_treatment Radioimmunoassay Nephrectomy Sensitivity and Specificity Gastroenterology Metastasis Renal cell carcinoma Internal medicine Biomarkers Tumor Carcinoma medicine Humans Carcinoma Renal Cell Neoplasm Staging Retrospective Studies Kidney biology Epithelioma business.industry medicine.disease Kidney Neoplasms Ferritin medicine.anatomical_structure Trypsin Inhibitor Kazal Pancreatic Creatinine biology.protein Female business |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1873-7560 0302-2838 |
| DOI: | 10.1159/000475165 |
| Popis: | In the absence of a specific marker for renal cell carcinoma (RCC), we evaluated the tumour-associated trypsin inhibitor (TATI) in patients with RCC. Between November 1990 and November 1993, 63 patients with RCC and 23 patients with benign renal disease underwent a competitive radioimmunoassay of TATI. The cutoff value was defined on a series of serum samples of 96 healthy subjects (normal n < 20 micrograms/l, then 25 micrograms/l after April 1993). We related the value of TATI to the tumour stage and compared the sensitivities of TATI and other markers (CEA, CA 15-3, CA 125, CA 19-9, ferritin). In 24 patients the TATI assay was repeated 3-12 months after radical nephrectomy. 15 patients with benign disease had a normal value of TATI (specificity: 65%). 44 of the 63 patients had a value of TATI above the cutoff point (sensitivity: 69%). Sensitivities of CEA, CA 15-3, CA 125, CA 19-9 and ferritin were 5, 10, 13, 5, 35%, respectively. The TATI value was correlated with the stage of the disease. Among the 15 patients without metastasis, the mean preoperative value was 112 micrograms/l (14-760) versus 46 micrograms/l (24-180) postoperatively. In the 9 patients with metastasis, the preoperative mean value was 100 micrograms/l (20-434) versus 240 micrograms/l (22-544) postoperatively. TATI showed a better sensitivity than other markers for RCC but its specificity is limited. Nevertheless it can be useful for a postoperative follow-up. TATI remains one of the best serum markers for RCC. |
| Databáze: | OpenAIRE |
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