Sporotrichosis by Sporothrix schenckii senso stricto with itraconazole resistance and terbinafine sensitivity observed in vitro and in vivo : Case report
| Autor: | Fernanda Fraga, Amanda Carvalho Ribeiro, Maria Lúcia Scroferneker, Carina Timotheo, Danielle Machado Pagani, Gerson Vettorato, Daiane Heidrich, Rodrigo Vettorato, Tais Guarienti Amaro |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antifungal medicine.medical_specialty Itraconazole medicine.drug_class Esporotricose 030106 microbiology Microbiology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine In vivo medicine Sporothrix schenckii Initial treatment Itraconazol lcsh:QH301-705.5 Terbinafine lcsh:R5-920 Sporotrichosis biology business.industry bacterial infections and mycoses medicine.disease biology.organism_classification Dermatology In vitro Senso stricto Infectious Diseases lcsh:Biology (General) lcsh:Medicine (General) Antifúngicos business Antifungal susceptibility medicine.drug |
| Zdroj: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Medical Mycology Case Reports, Vol 19, Iss C, Pp 18-20 (2018) |
| ISSN: | 2211-7539 |
| DOI: | 10.1016/j.mmcr.2017.10.001 |
| Popis: | We report a case of a patient with lymphocutaneous sporotrichosis in the right upper limb. The fungus was identified as Sporothrix schenckii senso stricto by calmodulin gene sequencing. The initial treatment was itraconazole (200 mg/day), but in vitro antifungal susceptibility demonstrated high resistant to this and another six antifungals, with exception to terbinafine. The lesions did not regress with itraconazole treatment. Thus, 500 mg/day of terbinafine was prescribed and clinical cure was obtained after four months |
| Databáze: | OpenAIRE |
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